Thank you all for your responses. This has been a steep learning curve for me and I now realise I was making some very silly assumptions in my original message when I thought the pin configuration in a PluX22 and a 21-pin MTC would be the same! I have now gone ahead and bought an ESU PluX12 to Next18 adapter lead and an R7345 Next18 decoder. I tried installing them in the loco today and everything seemed fine to start with. The decoder communicated with the HM7000 app on my iPad, I linked the device and even downloaded the 9F sound profile SD026 into it. I even got sound from the built-in speaker in the tender but as soon as I commanded the loco to move, the sound stopped and I noticed that the decoder was very hot! The decoder is now not communicating with the iPad and gets very hot every time I power it up.
If anyone has any ideas what could have happened, I would be grateful. I wondered if I may have got the orientation wrong with either of the connectors but if this was the case, why did it initially work ok? Could it perhaps be that the loco motor was pulling too much current? Do you think the decoder is redeemable or is it fried? The fact that it's getting hot and not communicating sounds like it's kaput, which is annoying as I only received it today!
Any views or advice would be welcome, thanks very much.